Block of Sodium Channels by Tyramine and Its Analogue (N-Feruloyl Tyramine) in Frog Ventricular Myocytes.
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چکیده
منابع مشابه
Effect of N-feruloyl tyramine (an analogue of tyramine) on inwardly rectifying potassium channel in frog ventricular myocytes.
Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 microM, while tyramine (100 ...
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متن کاملCardiac effects of tyramine.
• Tyramino (p-hydroxyphenylethylamine), the product of decarboxylation of tyrosine, has been known for a number of years to have pharmacological activity as a pressor substance." In a preparation of the atrium of the cat's heart in Locke-Ringer solution, Ajidrus, in 1 924, showed that tyramine increased the rate aud amplitude of atrial contractions. In 1926, Tainter reported the circulatory eff...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 1992
ISSN: 0021-521X
DOI: 10.2170/jjphysiol.42.179